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Chemical Structure : HAMI3379
Catalog No.: PC-35285Not For Human Use, Lab Use Only.
HAMI3379 (HAMI-3379) is a potent and selective antagonist of cysteinyl leukotriene 2 (CysLT(2)) receptor, inhibits LTD4- and LTC4-induced intracellular calcium mobilization withIC50 of 3.8 nM and 4.4 nM respectively.
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HAMI3379 (HAMI-3379) is a potent and selective antagonist of cysteinyl leukotriene 2 (CysLT(2)) receptor, inhibits LTD4- and LTC4-induced intracellular calcium mobilization withIC50 of 3.8 nM and 4.4 nM respectively; exhibits very low potency on a recombinant CysLT(1) receptors (IC50>10 uM), does not exhibit any agonistic activity on both CysLT receptors; concentration-dependently inhibits and reverses the LTC(4)-induced perfusion pressure increase and contractility decrease in isolated Langendorff-perfused guinea pig hearts, protects against acute brain injury after focal cerebral ischemia in rats.
| M.Wt | 595.733 | |
| Formula | C34H45NO8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Merten N, et al. Cell Chem Biol. 2018 Jun 21;25(6):775-786.e5.
2. Wunder F, et al. Br J Pharmacol. 2010 May;160(2):399-409.
3. Shi QJ, et al. Brain Res. 2012 Nov 12;1484:57-67.
4. Zhang XY, et al. J Pharmacol Exp Ther. 2013 Aug;346(2):328-41.
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