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HCH6-1

Chemical Structure : HCH6-1

CAS No.: 1435265-06-7

HCH6-1 (FPR1 antagonist)

Catalog No.: PC-20392Not For Human Use, Lab Use Only.

HCH6-1 is a selective, competitive formyl peptide receptor 1 (FPR1) antagonist, superoxide anion generation in fMLF (FPR1 agonist)-activated neutrophils with IC50 of 0.32 uM in cell-impermeable cytochrome c reduction assay.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

HCH6-1 is a selective, competitive formyl peptide receptor 1 (FPR1) antagonist, superoxide anion generation in fMLF (FPR1 agonist)-activated neutrophils with IC50 of 0.32 uM in cell-impermeable cytochrome c reduction assay.
HCH6-1 inhibits superoxide anion generation, elastase release, and chemotaxis in human neutrophils specifically activated by fMLF.
HCH6-1 significantly inhibits elastase release in fMLF-activated neutrophils with IC50 of 0.57 uM.
HCH6-1 reduces inflammatory cell infiltration and distortion of pulmonary architecture in the presence of LPS. HCH6-1 posttreatment shows inhibitory effects on neutrophil accumulation and lung damage in LPS-induced ALI mice

Physicochemical Properties

M.Wt 469.54
Formula C28H27N3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

methyl benzoyl-L-tryptophyl-D-phenylalaninate

References

1. Hung-Li Wang, et al. Biochem Pharmacol. 2023 Mar 29;115524.

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