Chemical Structure : HD202A
CAS No.:
2930131-74-9
HD202A
Catalog No.: PC-26314Not For Human Use, Lab Use Only.
HD202A is a highly potent, selective MNK1/2 inhibitor with IC50 of 6.1/8.1 nM respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
HD202A is a highly potent, selective MNK1/2 inhibitor with IC50 of 6.1/8.1 nM respectively.
HD202A displays marked selectivity for MNK1/2 across a 140-kinase panel.
HD202A suppressed MNK-eIF4E signaling, downregulated perilipin 2 and stearoyl-coenzyme A desaturase 1, upregulated adipose triglyceride lipase and peroxisome proliferator-activated receptor gamma coactivator 1α, and enhanced mitochondrial fatty-acid oxidation and redox homeostasis.
HD202A markedly reduced body-weight gain, hepatic triglyceride accumulation, and serum lipids while improving glucose tolerance, insulin sensitivity, and inflammatory profiles.
Physicochemical Properties
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M.Wt
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456.57
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Formula
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C25H24N6OS
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-(2-(4-(4-(Dimethylamino)piperidine-1-carbonyl)phenyl)imidazo[2,1-b][1,3,4]thiadiazol-5-yl)benzonitrile
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References
1. Qiu T, et al. J Med Chem. 2026 Mar 9. doi: 10.1021/acs.jmedchem.5c03316.
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