Catalog No.: PC-21118Not For Human Use, Lab Use Only.
HDAC3 PROTAC P7 is a potent and selective HDAC3-directed PROTAC with IC50 of 40 nM (HDAC3 deacetylase activity), effectively induces HDAC3 degradation with DC50 of 0.6 nM in THP-1 cells (Emax=90%).
HDAC3 PROTAC P7 is a potent and selective HDAC3-directed PROTAC with IC50 of 40 nM (HDAC3 deacetylase activity), effectively induces HDAC3 degradation with DC50 of 0.6 nM in THP-1 cells (Emax=90%).
HDAC3 PROTAC P7 not demonstrate a significant effect on the levels of HDAC1, HDAC2 and HDAC6, while significant effects on HDAC4 at >3.3 uM.
HDAC3 PROTAC P7 is a potent and selective HDAC3 PROTACthat can also trigger HDAC8 degradation at higher concentrations.
HDAC3 PROTAC P7 shows anti-inflammatory activityin THP-1 derivedM1-like macrophage, decreases the secretion of pro-inflammatory cytokines in M1-like macrophages derived from human primary macrophages.
