Chemical Structure : HF13141-H5
CAS No.:
688738-27-4
HF13141-H5
Catalog No.: PC-26237Not For Human Use, Lab Use Only.
HF13141-H5 is a potent, selective inhibitor of γ-Glutamyl carboxylase (GGCX) with IC50 of 240 nM-1 uM in cell-based assays, inhibits γ-carboxylation of vitamin K-dependent clotting factors (VKDCFs) and shows anticoagulant effect.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
HF13141-H5 is a potent, selective inhibitor of γ-Glutamyl carboxylase (GGCX) with IC50 of 240 nM-1 uM in cell-based assays, inhibits γ-carboxylation of vitamin K-dependent clotting factors (VKDCFs) and shows anticoagulant effect.
HF13141-H5 specifically inhibits GGCX activity without affecting vitamin K epoxide reductase (VKOR) function.
HF13141-H5 inhibited vitamin K epoxidation in a dose dependent manner, completely abolishing epoxidation activity at 20 uM in in vitro vitamin K epoxidation activity assay.
HF13141-H5 competitively inhibits GGCX by occupying the KH2 substrate-binding pocket.
HF13141-H5 mimics the binding of reduced vitamin K.
HF13141-H5 maintained full inhibitory potency against VKOR variants associated with warfarin resistance and demonstrated robust anticoagulant activity in a zebrafish laser-induced endothelial injury model.
Physicochemical Properties
|
M.Wt
|
415.45
|
|
Formula
|
C24H21N3O4
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
2-(1-oxophthalazin-2(1H)-yl)ethyl (4-(benzyloxy)phenyl)carbamate
|
References
1. Guomin Shen, et al. Blood Adv. 2025 Dec 22:bloodadvances.2025018776.
2. Patent CN113831293 A 2021-12-24.
Contact Us
sales@probechem.com
