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HF50731

Chemical Structure : HF50731

CAS No.: 2484771-19-7

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HF50731 (HF-50731)

Catalog No.: PC-72032Not For Human Use, Lab Use Only.

HF50731 (HF-50731) is a novel potent, selective CXCR4 antagonist with Ki of 19.8 nM in the CXCR4 competitive binding assay.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    HF50731 (HF-50731) is a novel potent, selective CXCR4 antagonist with Ki of 19.8 nM in the CXCR4 competitive binding assay.
    HF50731 significantly inhibited SDF-1α-induced calcium mobilization (IC50=621 nM) and cell migration, and blocked HIV-1 infection via antagonizing CXCR4 coreceptor function (IC50=1.5 uM).
    The structure-activity relationship analysis demonstrated that HF50731 could primarily occupy the minor subpocket of CXCR4 and partially bind in the major subpocket by interacting with residues W94, D97, D171, and E288.

    Physicochemical Properties

    M.Wt 414.682
    Formula C26H46N4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N1,N1'-(1,4-phenylenebis(methylene))bis(N3-cyclohexylpropane-1,3-diamine)

    References

    1. Xiong Fang, et al. Eur J Med Chem. 2020 Aug 15;200:112410.

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