Chemical Structure : HGC652
CAS No.:
3055558-98-7
HGC652
(HGC-652)
Catalog No.: PC-24423Not For Human Use, Lab Use Only.
HGC652 is an E3 ubiquitin ligase TRIM21-dependent molecular glue degrader (TRIM21 Kd=0.06 uM), induces TRIM21-NUP98 interaction and causes selective degradation of nuclear pore complex proteins.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
HGC652 is an E3 ubiquitin ligase TRIM21-dependent molecular glue degrader (TRIM21 Kd=0.06 uM), induces TRIM21-NUP98 interaction and causes selective degradation of nuclear pore complex proteins.
HGC652 induced polyubiquitination of SmF-EGFP-SH3-NUP98APD and SmF-EGFP-PRM in CEBIT assays.
HGC652 also induced the formation of TRIM21-NUP98 complex as shown by the Strep-tag pull-down assays.
HGC652 demonstrated dose-dependent growth inhibition against 8 cancer cell lines with IC50 of 0.106-0.822 uM.
Physicochemical Properties
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M.Wt
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449.60
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Formula
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C23H28FNO3S2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(cyclohexylmethyl)-4'-fluoro-N-methyl-3-(methylsulfonyl)-2'-(methylthio)-[1,1'-biphenyl]-4-carboxamide
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References
1. Li X, et al. ACS Chem Biol. 2025 Apr 18. doi: 10.1021/acschembio.4c00833.
2. Patent WO2024179572 A1.
3. Li, X, et al. Chemically Induced Nuclear Pore Complex Protein Degradation via E3 Ligase TRIM21. bioRxiv 2024, DOI: 10.1101/2024.12.03.626577
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