HJ-PI01 is a novel small molecule inhibitor of Pim2, inhibits Pim-2 and induces apoptosis and autophagy in MDA-MB-231 cells. HJ-PI01 displayed excellent inhibitory activity of up to 76.5% at a 1 μmol/L concentration in MDA-MB-231 cells. HJ-PI01 induces autophagic death in MDA-MB-231 cells HJ-PI01 induces death receptor-dependent and mitochondrial apoptosis HJ-PI01 (40 mg/kg) significantly inhibited tumor growth in xenograft mouse model using MDA-MB-231 cells.
Physicochemical Properties
M.Wt
225.25
Formula
C14H11NO2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
1-(10H-Phenoxazin-10-yl)ethan-1-one
References
1. Zhao YQ, et al. Acta Pharmacol Sin. 2016 Sep;37(9):1237-50.
