HK262 | METTL21A inhibitor | Probechem Biochemicals

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Chemical Structure : HK262

HK262 (HK-262)

Catalog No.: PC-27762Not For Human Use, Lab Use Only.

HK262 is a first-in-class, specific inhibitor of protein lysine methyltransferase METTL21A with IC50 of 1.1 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

HK262 is a first-in-class, specific inhibitor of protein lysine methyltransferase METTL21A with IC50 of 1.1 uM.
METTL21A is a protein lysine MTase responsible for the trimethylation of HSP70 family members.
HK262 has approximately 68-fold improvement in inhibitory activity compared to the endogenous product inhibitor SAH (IC50=74.4 uM).
HK262 is stable in both plasma and liver microsomes.
HK262 exhibits a cytotoxic effect against HepG2 (CC50=8 uM).

Physicochemical Properties

M.Wt	482.39
Formula	C16H15F5N6O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C([C@H]1O[C@@H](N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O)NC4=CC=C(S(F)(F)(F)(F)F)C=C4

References

1. Kocek H, et al. Eur J Med Chem. 2026 Aug 11;319:119227.

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HK262 (HK-262)

Biological Activity

Physicochemical Properties

References

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