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Chemical Structure : HNPMI
Catalog No.: PC-20818Not For Human Use, Lab Use Only.
HNPMI is a small molecule inhibitor of epidermal growth factor receptor (EGFR) with the anticancer potential against various cancers.
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HNPMI is a small molecule inhibitor of epidermal growth factor receptor (EGFR) with the anticancer potential against various cancers.
HNPMI significantly reduced the cell proliferation of MCF-7 and SkBr3 cells, without affecting non-cancerous cells, H9C2.
HNPMI induces G0/G1 phase arrest in CRC cells.
HNPMI altered several apoptotic-related proteins including Caspase 3, BCL-2, and p53.
HNPMI significantly downregulated the crucial proteins associated with oncogenesis in CRC cells.
HNPMI reduced tumor volume in xenograft mice.
| M.Wt | 360.41 | |
| Formula | C22H20N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kandhavelu J, et al. Br J Pharmacol. 2023 May 15. doi: 10.1111/bph.16141.
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