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Chemical Structure : HPI-1
CAS No.: 599150-20-6
Catalog No.: PC-62179Not For Human Use, Lab Use Only.
HPI-1 is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Shh (IC50=1.5 uM) without significantly affecting Wnt signaling (IC50>30 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $218 | In stock | |
| 50 mg | $378 | In stock | |
| 100 mg | $528 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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HPI-1 is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Shh (IC50=1.5 uM) without significantly affecting Wnt signaling (IC50>30 uM).
HPI-1 suppresses Hh activation induced by loss of Suppressor of Fused or by Gli overexpression.
HPI-1 inhibits signaling through the oncogenic Smoothened (Smo) mutant SmoM2 in neuron precursors, preventing cell proliferation.
| M.Wt | 463.5 | |
| Formula | C27H29NO6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1,4,5,6,7,8-Hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylic acid 2-methoxyethyl ester |
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1. Hyman JM, et al. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14132-7.
2. Xu Y, et al. Clin Cancer Res. 2012 Mar 1;18(5):1291-302.
3. Chenna V, et al. Mol Cancer Ther. 2012 Jan;11(1):165-73.
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