Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : HQY426
CAS No.:
Catalog No.: PC-21416Not For Human Use, Lab Use Only.
HQY426 is a specific, orally bioavailable inhibitor of pre-messenger RNA endonuclease cleavage and polyadenylation specificity factor 3 (CPSF3) with binding IC50 of 0.32 uM, exhibits potent antitumor activity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $258 | In stock | |
| 5 mg | $398 | In stock | |
| 10 mg | $558 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
HQY426 is a specific, orally bioavailable inhibitor of pre-messenger RNA endonuclease cleavage and polyadenylation specificity factor 3 (CPSF3) with binding IC50 of 0.32 uM, exhibits potent antitumor activity.
HQY426 suppresses cell proliferation and causes G2-M arrest and apoptosis in ovarian cancer cells.
HQY426 (10 mg/kg per day) exhibits potent therapeutic efficacy and low systemic toxicity in SKOV3 xenografts BALB/c nude mice.
HQY426 effectively exacerbated genomic instability by down-regulating DNA damage repair genes and thus acted in synergy with poly(adenosine 5'-diphosphate–ribose) polymerase inhibition.
| M.Wt | 366.22 | |
| Formula | C20H23BN2O4 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-7-yl)-N-(3-morpholinophenyl)propanamide |
|
1. Shen P, et al. Sci Adv. 2023 Nov 24;9(47):eadj0123.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
