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Chemical Structure : HR22C16
Catalog No.: PC-70047Not For Human Use, Lab Use Only.
HR22C16 (Monastroline) is a potent, selective and cell permeable inhibitor of mitotic kinesin Eg5 with IC50 of 0.8 uM, does not interact with other microtubule motor proteins.
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HR22C16 (Monastroline) is a potent, selective and cell permeable inhibitor of mitotic kinesin Eg5 with IC50 of 0.8 uM, does not interact with other microtubule motor proteins.
HR22C16 (Monastroline) inhibits cell survival in both Taxol-sensitive and -resistant ovarian cancer cells with at least 15-fold greater efficacy than monastrol.
| M.Wt | 389.455 | |
| Formula | C23H23N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hotha S, et al. Angew Chem Int Ed Engl. 2003 May 30;42(21):2379-82.
2. Marcus AI, et al. J Biol Chem. 2005 Mar 25;280(12):11569-77.
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