Chemical Structure : HSD17B13 inhibitor 32
CAS No.:
3075100-76-1
HSD17B13 inhibitor 32
Catalog No.: PC-24627Not For Human Use, Lab Use Only.
HSD17B13 inhibitor 32 is a highly potent, selective and liver-targeting HSD17B13 inhibitor with IC50 of 2.5 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
HSD17B13 inhibitor 32 is a highly potent, selective and liver-targeting HSD17B13 inhibitor with IC50 of 2.5 nM.
HSD17B13 inhibitor 32 exhibits binding affinity (hKd = 19.3 nM) and inhibitory activity against murine HSD17B13 (IC50=55.1 nM).
HSD17B13 inhibitor 32 exhibits high selectivity (>100-fold) over other key MASH-related targets, including fatty-acid-binding proteins 1/4 (FABP1/4), free fatty acid receptor 1 (FFAR1), and 17 nuclear hormone receptors.
HSD17B13 inhibitor 32 maintains potent inhibition of HSD17B13 (IC50 = 7.6 nM) in enzymatic assay using leukotriene B4 (LTB4) as a cosubstrate.
HSD17B13 inhibitor 32 exhibits robust anti-MASH effects by regulating lipid metabolism, inflammation, fibrosis, and oxidative stress in diet-induced obesity (DIO) and MASH mouse models.
Physicochemical Properties
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M.Wt
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454.89
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Formula
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C21H18ClF3N2O2S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(4-Chlorobenzyl)-N-isopropyl-4-methyl-2-(2,4,5-trifluoro-3-hydroxyphenyl)thiazole-5-carboxamide
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References
1. Lianru Chen, et al. J Med Chem. 2025 May 19. doi: 10.1021/acs.jmedchem.5c00119.
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