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Chemical Structure : HTH-01-015
CAS No.: 1613724-42-7
Catalog No.: PC-42982Not For Human Use, Lab Use Only.
HTH-01-015 is a potent, specific NUAK1 (AMPK-related kinase 5, ARK5) inhibitor with IC50 of 100 nM, displays >100-fold higher potency than NUAK2.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $228 | In stock | |
| 50 mg | $368 | In stock | |
| 100 mg | Get quote |
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HTH-01-015 is a potent, specific NUAK1 (AMPK-related kinase 5, ARK5) inhibitor with IC50 of 100 nM, displays >100-fold higher potency than NUAK2.
HTH-01-015 also does not markedly suppress the activity of any of the other 139 protein kinases, including AMPK.
HTH-01-015 suppresses NUAK1-mediated MYPT1 phosphorylation in vivo, the NUAK1 mutation (A195T) renders resistant to HTH-01-015.
HTH-01-015 significantly inhibits migration the proliferation of MEFs (mouse embryonic fibroblasts).
| M.Wt | 468.5535 | |
| Formula | C26H28N8O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6H-Naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one, 5,13-dihydro-4,5,13-trimethyl-2-[[1-(4-piperidinyl)-1H-pyrazol-4-yl]amino]- |
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1. Banerjee S, et al. Biochem J. 2014 Jan 1;457(1):215-25.
2. Banerjee S, et al. Biochem J. 2014 Jul 15;461(2):233-45.
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