HW201877 | 15-PGDH inhibitor | Probechem Biochemicals

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Chemical Structure : HW201877

HW201877 (HW-201877)

Catalog No.: PC-24859Not For Human Use, Lab Use Only.

HW201877 is a potent, selective and orally active 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor with IC50 of 3.6 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

HW201877 is a potent, selective and orally active 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor with IC50 of 3.6 nM.
HW201877 exhibits robust cellular efficacy in elevating PGE2 levels in A549 cells (4.8-fold increase vs control).
HW201877 (0.5, 1.0, or 2.0 mg/kg, BID) marked reductions in pulmonary fibrosis scores, achieving comparable therapeutic efficacy in a bleomycin-induced rat pulmonary fibrosis model.

Physicochemical Properties

M.Wt	440.45
Formula	C22H22F2N6O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	7-[(1aS,7bR)-6-(4,4-difluoropiperidine-1-carbonyl)-1,1a,2,7b-tetrahydro-3H-cyclopropa[c][1,8]naphthyridin-3-yl]-2-methyl[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one

References

1. Qun Li, et al. J Med Chem. 2025 Jun 26. doi: 10.1021/acs.jmedchem.5c01361.

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HW201877 (HW-201877)

Biological Activity

Physicochemical Properties

References

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