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459147-39-8 A potent and selective inhibitor of 15-PGDH with Ki of 0.1 nM, IC50 of 1.5 nM; increases PGE2 levels by 3.5-fold at 500 nM, with EC50 of 75 nM; increases prostaglandin PGE2 levels in bone marrow and other tissues, accelerates hematopoietic recovery in mice receiving a bone marrow transplant; also promotes tissue regeneration in mouse models of colon and liver injury.

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