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Chemical Structure : HYPE inhibitor I2.10
Catalog No.: PC-22137Not For Human Use, Lab Use Only.
HYPE inhibitor I2.10 is a small molecule HYPE (Huntingtin Yeast Interacting Partner E, FICD) enzyme inhibitor with IC50 of 12.1 uM, inhibits HYPE-mediated AMPylation of BiP in vtro.
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HYPE inhibitor I2.10 is a small molecule HYPE (Huntingtin Yeast Interacting Partner E, FICD) enzyme inhibitor with IC50 of 12.1 uM, inhibits HYPE-mediated AMPylation of BiP in vtro.
HYPE resides in the ER (endoplasmic reticulum) where it AMPylates the heat shock chaperone BiP (Binding Immunoglobulin Protein).
| M.Wt | 279.26 | |
| Formula | C14H9N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ali Camara, et al. Cell Stress Chaperones. 2024 Apr 8:S1355-8145(24)00063-4.
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