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Chemical Structure : Harmine
Catalog No.: PC-35649Not For Human Use, Lab Use Only.
Harmine (Telepathine, Banisterine, Leucoharmine) is a fluorescent harmala alkaloid occurs in a number of different plants, reversibly inhibits monoamine oxidase A (MAO-A) but not MAO-B, also inhibits multiple TWIST1 functions.
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Harmine (Telepathine, Banisterine, Leucoharmine) is a fluorescent harmala alkaloid occurs in a number of different plants, reversibly inhibits monoamine oxidase A (MAO-A) but not MAO-B, also inhibits multiple TWIST1 functions; targeted the TWIST1 pathway through its promotion of TWIST1 protein degradation, inhibits single-cell dissemination, suppression of normal branching in 3D epithelial culture, and proliferation of oncogene driver-defined NSCLC cells (IC50=22 uM) also shows DYRK1A inhibitory activity, induces β-cell proliferation both in vitro and in vivo.
| M.Wt | 212.252 | |
| Formula | C13H12N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Spies M, et al. Transl Psychiatry. 2018 Sep 21;8(1):198.
2. Yochum ZA, et al. Oncogene. 2018 Aug 31. doi: 10.1038/s41388-018-0482-y.
3. Yochum ZA, et al. Mol Cancer Res. 2017 Dec;15(12):1764-1776.
4. Kumar K, et al. J Med Chem. 2018 Sep 13;61(17):7687-7699.
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