Hemi-ubistatin | Ubiquitin-proteasome system inhibitor

Chemical Structure : Hemi-ubistatin

Hemi-ubistatin (h-ubiB)

Catalog No.: PC-27978Not For Human Use, Lab Use Only.

Hemi-ubistatin B (h-ubiB) is a small molecule inhibitor of proteasome-dependent degradation by binding the ubiquitin chain, binds ubiquitin and diubiquitin, shows strong preference for K48-linkages over K11 and K63, penetrates cancer cells and alters the cellular ubiquitin landscape.

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Biological Activity

Physicochemical Properties

M.Wt	449.36
Formula	C16H9N3Na2O6S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	sodium 2-(3-sulfonatophenyl)-2H-naphtho[1,2-d][1,2,3]triazole-7-sulfonate

References

1. Verma R, et al. Science. 2004 Oct 1;306(5693):117-20.

2. Nakasone MA, et al. Structure. 2017 Dec 5;25(12):1839-1855.e11.

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Hemi-ubistatin (h-ubiB)

Biological Activity

Physicochemical Properties

References

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