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Chemical Structure : HlyU inhibitor CM14
Catalog No.: PC-36127Not For Human Use, Lab Use Only.
HlyU inhibitor CM14 (1025E12) is a specifc, small-molecule inhibitor of transcriptional regulator HlyU activity with EC50 of 30.97 uM, inhibits HlyU from binding to target DNA by covalently modifying Cys30.
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HlyU inhibitor CM14 (1025E12) is a specifc, small-molecule inhibitor of transcriptional regulator HlyU activity with EC50 of 30.97 uM, inhibits HlyU from binding to target DNA by covalently modifying Cys30; reduces HlyU-dependent expression of virulence genes in V. vulnificus. In addition to the decreased hemolysis of human erythrocytes without affecting bacterial growth or triggering the host cell death; also reduces HlyU-dependent expression of virulence genes in V. vulnificus, decreases the expression of various virulence genes of other Vibrio species and thus attenuates their virulence phenotypes.
| M.Wt | 345.372 | |
| Formula | C20H11NO3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lee ZW, et al. Sci Rep. 2019 Mar 13;9(1):4346. doi: 10.1038/s41598-019-39554-y.
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