Catalog No.: PC-26593Not For Human Use, Lab Use Only.
Huib32 is a potent, selective small-molecule inhibitor of USP32 with IC50 of 21.2 nM, high selectivity over other closely related deubiquitinating enzymes (DUBs).
Huib32 is a potent, selective small-molecule inhibitor of USP32 with IC50 of 21.2 nM in an activity assay using Ub-RhoMP.
Huib32 shows high selectivity over other closely related deubiquitinating enzymes (DUBs), such as USP8/10/16, UCHL1 and OTUB2.
Huib32 reversibly inhibits USP32 by covalently binding to the active site Cys743, which enhances substrate ubiquitination, alters endosomal morphology, and mimics USP32 depletion.
