Chemical Structure : HypoxyStat
CAS No.:
2414508-40-8
HypoxyStat
Catalog No.: PC-24293Not For Human Use, Lab Use Only.
HypoxyStat is a small molecule that increase oxygen-hemoglobin binding affinity cause tissue hypoxia, binds hemoglobin, induces systemic hypoxia in mice breathing normoxic (21% O2) air.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
HypoxyStat is a small molecule that increase oxygen-hemoglobin binding affinity cause tissue hypoxia, binds hemoglobin, induces systemic hypoxia in mice breathing normoxic (21% O2) air.
HypoxyStat results in tissue hypoxia that is comparable to therapeutic inhaled hypoxia.
HypoxyStat improves survival and outcomes of Ndufs4 KO model of Leigh syndrome.
HypoxyStat not only extends lifespan but also rescues key neuropathological and behavioral deficits in the premier mouse model of Leigh syndrome.
HypoxyStat reverses very late stage of disease (∼P50) in Ndufs4 KO mice.
Physicochemical Properties
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M.Wt
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367.40
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Formula
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C21H21NO5
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-[[(2S)-1-(2-Formylbenzoyl)-2-piperidinyl]methoxy]-6-hydroxybenzaldehyde
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References
1. Blume SY, et al. Cell. 2025 Feb 12:S0092-8674(25)00098-4.
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