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I-BET469

Chemical Structure : I-BET469

CAS No.: 2003197-53-1

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I-BET469 (I-BET 469)

Catalog No.: PC-22528Not For Human Use, Lab Use Only.

I-BET469 is a potent, selective pan-BET bromodomain inhibitor with pIC50 of 7.9 for BRD4 BD1, >5000-fold selective over BAZ2A.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    I-BET469 is a potent, selective pan-BET bromodomain inhibitor with pIC50 of 7.9 for BRD4 BD1, >5000-fold selective over BAZ2A.
    I-BET469 inhibits human whole blood MCP-1 with an pIC50 value of 7.6, inhibits LPS-stimulated hWB IL-6 with pIC50 of 7.7.

    Physicochemical Properties

    M.Wt 426.52
    Formula C23H30N4O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-(1-(1,3-Dimethoxypropan-2-yl)-5-morpholino-1H-benzo[d]imidazol-2-yl)-1,3-dimethylpyridin-2(1H)-one

    References

    1. Christopher R Wellaway, et al. J Med Chem. 2020 Jan 23;63(2):714-746.

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