I-BET567 | pan-BET inhibitor | Probechem Biochemicals

Chemical Structure : I-BET567

CAS No.: 1887237-54-8

Catalog No.: PC-72646Not For Human Use, Lab Use Only.

I-BET567 (GSK3383567) is a potent, oral pan-BET inhibitor with Ki of 5-40 nM against BD1/ BD2 of BRD2/3/4/BRDT.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

I-BET567 (GSK3383567) is a potent, oral pan-BET inhibitor with Ki of 5-40 nM against BD1/ BD2 of BRD2/3/4/BRDT.

I-BET567 (GSK3383567) effectively inhibited the proliferation of human NMC cell line 11060 in vitro with mean IC50 of 0.63 uM.

I-BET567 (30 mg/kg) demonstrated tumor growth inhibition in the mouse NMC xenograft model.

M.Wt	359.814
Formula	C17H18ClN5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,4R)-1-acetyl-4-((5-chloropyrimidin-2-yl)amino)-2-methyl-1,2,3,4-tetrahydroquinoline-6-carboxamide

1. Philip G Humphreys, et al. J Med Chem. 2022 Feb 10;65(3):2262-2287.