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Chemical Structure : I-BET726
CAS No.: 1300031-52-0
Catalog No.: PC-43808Not For Human Use, Lab Use Only.
I-BET726 (GSK1324726A) is a potent and selective inhibitor of BET bromodomain with IC50 of 41 nM/31 nM/22 nM for BRD2/BRD3/BRD4 respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $178 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | Get quote |
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I-BET726 (GSK1324726A) is a potent and selective inhibitor of BET bromodomain with IC50 of 41 nM/31 nM/22 nM for BRD2/BRD3/BRD4 respectively.
I-BET726 (GSK1324726A) exhibits growth inhibition with a median growth IC50 value of 75 nM in neuroblastoma cell lines.
I-BET726 (GSK1324726A) oral administration to mouse xenograft models of human neuroblastoma results in tumor growth inhibition and down-regulation MYCN and BCL2 expression.
| M.Wt | 434.9147 | |
| Formula | C25H23ClN2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 46 mg/mL |
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| Chemical Name/SMILES |
Benzoic acid, 4-[(2S,4R)-1-acetyl-4-[(4-chlorophenyl)amino]-1,2,3,4-tetrahydro-2-methyl-6-quinolinyl]- |
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1. Gosmini R, et al. J Med Chem. 2014 Oct 9;57(19):8111-31.
2. Wyce A, et al. PLoS One. 2013 Aug 23;8(8):e72967.
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