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Chemical Structure : IACS-15414
Catalog No.: PC-38186Not For Human Use, Lab Use Only.
IACS-15414 (IACS 15414) is a potent, selective, orally bioavailable SHP2 inhibitor with IC50 of 122 nM.
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IACS-15414 (IACS 15414) is a potent, selective, orally bioavailable SHP2 inhibitor with IC50 of 122 nM.
IACS-15414 potently suppressed the mitogen-activated protein kinase (MAPK) pathway signaling and tumor growth in RTK-activated and KRASmut xenograft models in vivo.
IACS-15414 potently suppressed the mitogen-activated protein kinase (MAPK) pathway signaling and tumor growth.
IACS-15414 had excellent PK properties across species but a narrow hERG window.
| M.Wt | 423.338 | |
| Formula | C20H24Cl2N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Barbara Czako, et al. J Med Chem. 2021 Oct 28;64(20):15141-15169.
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