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Chemical Structure : IACS-9571 hydrochloride
CAS No.: 2319611-93-1
Catalog No.: PC-21929Not For Human Use, Lab Use Only.
IACS-9571 hydrochloride is a potent, selective dual TRIM24-BRPF1 bromodomain inhibitor with Kd of 31 and 14 nM, respectively.
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|---|---|---|---|
| 5 mg | $258 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $588 | In stock | |
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IACS-9571 hydrochloride is a potent, selective dual TRIM24-BRPF1 bromodomain inhibitor with Kd of 31 and 14 nM, respectively.
IACS-9571 displays 9- and 21-fold selectivity against BRPF2 and BRPF3, weaker affinities with BAZ2B (Kd= 400 nM) and the second domain of TAF1 (Kd=1,800 nM), and >7,700-fold selectivity versus BRD4 BD1 and BD2.
IACS-9571 demonstrates excellent cellular potency (EC50= 50 nM) and favorable pharmacokinetic properties.
IACS-9571 is a chemical probe to investigate biological and pharmacological role of TRIM24 and/or BRPF1 bromodomain inhibition in vitro and in vivo.
| M.Wt | 679.23 | |
| Formula | C32H43ClN4O8S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(6-(3-(4-(dimethylamino)butoxy)-5-propoxyphenoxy)-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-3,4-dimethoxybenzenesulfonamide hydrochloride |
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1. Gechijian LN, et al. Nat Chem Biol. 2018 Mar 5. doi: 10.1038/s41589-018-0010-y.
2. Palmer WS, et al. J Med Chem. 2016 Feb 25;59(4):1440-54.
3. Appikonda S, et al. J Biol Chem. 2018 Mar 9. pii: jbc.RA118.002233.
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