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IBG4

Chemical Structure : IBG4

CAS No.: 2851986-83-7

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IBG4 (BRD4 degrader)

Catalog No.: PC-21847Not For Human Use, Lab Use Only.

IBG4 is a selective, DCAF11-based intramolecular glue/degrader of BRD4, functions via CRL4-DCAF11, shows high specificity for BRD4 and does not efficiently degrade BRD2.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    IBG4 is a selective, DCAF11-based intramolecular glue/degrader of BRD4, functions via CRL4-DCAF11, shows high specificity for BRD4 and does not efficiently degrade BRD2.

    Physicochemical Properties

    M.Wt 647.73
    Formula C34H30FN9O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-N-(4'-(6-(2-(dimethylamino)-2-oxoethyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-4-fluoro-[1,1'-biphenyl]-3-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

    References

    1. Oliver Hsia, et al. Nature. 2024 Feb 21. doi: 10.1038/s41586-024-07089-6.

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