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Chemical Structure : ICA-069673
CAS No.: 582323-16-8
Catalog No.: PC-60823Not For Human Use, Lab Use Only.
ICA-069673 (ICA069673) is a novel potent, selective and orally active KCNQ2/Q3 (Kv7.2/Kv7.3) potassium channel opener/activator with EC50 of 0.69 uM, 20-fold selectivity over KCNQ3/Q5.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $188 | In stock | |
| 50 mg | $348 | In stock | |
| 100 mg | $628 | In stock | |
| 500 mg | Get quote | ||
| 1 g | Get quote |
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ICA-069673 (ICA069673) is a novel potent, selective and orally active KCNQ2/Q3 (Kv7.2/Kv7.3) potassium channel opener/activator with EC50 of 0.69 uM, 20-fold selectivity over KCNQ3/Q5.
ICA-069673 displays no measurable activity against a panel of cardiac ion channels (IC50>30 uM for hERG, Nav1.5, L type channels, and KCNQ1) as well as no activity on GABA(A) gated channels.
ICA-069673 also robustly activates Kv7.4 channels, inhibits spontaneous phasic, pharmacologically induced, and nerve-evoked contractions in DSM isolated strips, decreases the global intracellular Ca(2+) concentration in DSM cells.
| M.Wt | 269.636 | |
| Formula | C11H6ClF2N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(2-chloro-pyrimidin-5-yl)-3,4-difluoro-benzamide |
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1. Amato G, et al. ACS Med Chem Lett. 2011 Mar 31;2(6):481-4.
2. Brueggemann LI, et al. Mol Pharmacol. 2014 Sep;86(3):330-41.
3. Provence A, et al. J Pharmacol Exp Ther. 2015 Sep;354(3):290-301.
4. Rivera-Arconada I, et al. Oncotarget. 2017 Feb 21;8(8):12554-12555.
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