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Chemical Structure : ICA-121431
CAS No.: 313254-51-2
Catalog No.: PC-45079Not For Human Use, Lab Use Only.
A potent, selective small molecule human Nav1.3/Nav1.1 channel inhibitor with IC50 of 19 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
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ICA-121431 is a potent, selective small molecule human Nav1.3/Nav1.1 channel inhibitor with IC50 of 19 nM.
ICA-121431 exhibits up to 1,000-fold selectivity over other TTX-sensitive or resistant (i.e., Nav1.5) sodium channels.
ICA-121431 also shows an intermediate sensitivity (IC50=240 nM) for Nav1.2.
| M.Wt | 449.5453 | |
| Formula | C23H19N3O3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 44 mg/mL |
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| Chemical Name/SMILES |
Benzeneacetamide, α-phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]- |
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1. McCormack K, et al. Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):E2724-32.
2. Osteen JD, et al. Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):6836-6841.
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