Chemical Structure : ICA00600232
CAS No.:
ICA00600232
(ICA-00600232)
Catalog No.: PC-25532Not For Human Use, Lab Use Only.
ICA00600232 is a potent, selective small molecule Nav1.1 sodium channel potentiator with EC50 of 24 nM, exhibits >1000-fold selectivity for human Nav1.1 over all other Nav1.x family members except Nav1.3 (EC50=98 nM).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ICA00600232 is a potent, selective small molecule Nav1.1 sodium channel potentiator with EC50 of 24 nM, exhibits >1000-fold selectivity for human Nav1.1 over all other Nav1.x family members except Nav1.3 (EC50=98 nM).
ICA00600232 displays comparative EC50s for Nav1.1 potentiation for rodents (mouse and rat), dog, pig, and nonhuman primates (marmoset and cynomolgus monkey), with 2- to 5-fold different from the 24 nM (human Nav1.1).
ICA00600232 (1 uM) produces an 11 mV depolarizing shift in voltage-dependence of activation of human Nav1.1 and a larger 23 mV depolarizing shift in voltage-dependence of steady-state inactivation.
ICA00600232 interacts with homologous domain 4 of Nav1.1.
ICA00600232 (10 nM-1 uM) increases excitability of cortical interneurons from scn1a+/− and wild-type mice.
Physicochemical Properties
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M.Wt
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451.48
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Formula
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C24H23F2N5O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(4-(2,5-difluorophenyl)-6-(2-oxa-6-azaspiro[3.3]heptan-6-yl)pyrimidin-5-yl)-6-isopropyl nicotinamide
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References
1. Gallucci A, et al. Mol Pharmacol. 2025 Aug 21;107(10):100072.
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