Chemical Structure : ICA604025
CAS No.:
ICA604025
(ICA-604025)
Catalog No.: PC-26899Not For Human Use, Lab Use Only.
ICA604025 is a potent, selective sodium channel Nav1.9 subtype inhibitor, inhibits human Nav1.9 in a state dependent manner with EC50s of 9 nM and 1.1 μM for the activated/inactivated state versus resting closed state.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ICA604025 is a potent, selective sodium channel Nav1.9 subtype inhibitor, inhibits human Nav1.9 in a state dependent manner with EC50s of 9 nM and 1.1 μM for the activated/inactivated state versus resting closed state.
ICA604025 exhibits a similar potency for inhibition of cynomolgus monkey Nav1.9 but ∼50-fold lower potency for inhibition of rodent Nav1.9.
ICA604025 is a 300- to 1800-fold more potent inhibitor of human Nav1.9 compared with other human Nav1.x family members.
Nav1.9 is a voltage-gated sodium channel genetically associated with human pain disorders and thus is a key target for new analgesics.
Physicochemical Properties
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M.Wt
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378.30
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Formula
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C16H15F5N2O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(R)-N-(2,2-difluoroethyl)-4-(7-(trifluoromethyl) benzofuran-2-yl) morpholine-2-carboxamide
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References
1. Potet F, et al. Mol Pharmacol. 2026 May 5;108(5-6):100125.
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