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Chemical Structure : ICCB-19
CAS No.: 750621-52-4
Catalog No.: PC-38287Not For Human Use, Lab Use Only.
ICCB-19 is a small molecule that binds to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | $428 | In stock | |
| 250 mg | Get quote |
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ICCB-19 is a small molecule that binds to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N).
TRADD-N interacts with the C-terminal domain (TRADD-C) and TRAF2 to modulate the ubiquitination of RIPK1 and beclin 1.
ICCB-19 indirectly inhibited RIPK1, inhibited (bortezomib)-induced apoptosis and RDA with IC50 of 1 uM.
ICCB-19 effectively induced autophagy and the degradation of long-lived proteins.
Inhibition of TRADD by ICCB-19 or Apt-1 (Apostatin-1, Cat. PC-38288) blocks apoptosis and restores cellular homeostasis by activating autophagy in cells with accumulated mutant tau, α-synuclein, or huntingtin.
| M.Wt | 255.38 | |
| Formula | C12H21N3OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-cycloheptyl-2-((4,5-dihydro-1H-imidazol-2-yl)thio)acetamide |
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1. Daichao Xu, et al. Nature. 2020 Nov;587(7832):133-138.
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