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Chemical Structure : ICEC 0942 hydrochloride
CAS No.: 1805789-54-1
Catalog No.: PC-35095Not For Human Use, Lab Use Only.
ICEC 0942 (Samuraciclib, CT7001) hydrochloride is a potent, selective, orally active CDK7 inhibitor with IC50 of 41 nM, displays 15-fold selectivity over CDK2 (IC50=578 nM).
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|---|---|---|---|
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| 10 mg | $328 | In stock | |
| 25 mg | $548 | In stock | |
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ICEC 0942 (Samuraciclib, CT7001) hydrochloride is a potent, selective, orally active CDK7 inhibitor with IC50 of 41 nM, displays 15-fold selectivity over CDK2 (IC50=578 nM).
ICEC0942 displays 45-, 15-, 230- and 30-fold selectivity over CDK1, CDK2, CDK5 and CDK9.
ICEC0942 demonstrates sensitivity against a wide range of cancer types with GI50 values ranging between 0.2-0.3 uM.
ICEC0942 shows substantial anti-tumor effects in xenografts of both breast and colorectal cancers, also exhibits complete growth arrest of ER-positive tumor xenografts combined with tamoxifen.
| M.Wt | 430.981 | |
| Formula | C22H31ClN6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(3R,4R)-4-(((7-(benzylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-5-yl)amino)methyl)piperidin-3-ol hydrochloride |
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1. Hazel P, et al. ChemMedChem. 2017 Mar 7;12(5):372-380.
2. Patel H, et al. Mol Cancer Ther. 2018 Mar 15. pii: molcanther.0847.2016.
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