Chemical Structure : IDB-003
CAS No.:
3079716-11-0
IDB-003
(IDB003)
Catalog No.: PC-26086Not For Human Use, Lab Use Only.
IDB-003 is an orally active, unique context-dependent inhibitor of human translation that bind to the ribosome peptidyl transferase center (PTC) and inhibits elongation.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
IDB-003 is an orally active, unique context-dependent inhibitor of human translation that bind to the ribosome peptidyl transferase center (PTC) and inhibits elongation.
IDB-003 potently inhibited cell proliferation in MYC-dependent cancer cell lines, including prostate (22Rv1), colorectal (LS411N), HR+, HER2- breast (MCF7) and TNBC (HCC-1143) when compared to fibroblasts (MRC5), with EC50 values in the nanomolar range. Treatment of MCF7 cells with 1 µM IDB-003 led to rapid depletion of CCND1 evident by 1–2 h and reduction in MYC levels observable after 2 h of treatment.
IDB-003 stalled ribosomes within the coding sequences of MYC, CCND1 and CDK4, supporting a direct mechanism for their depletion.
IDB-003 inhibits tumor growth of MDA-MB-231 xenografts in vivo and depletes short-lived oncoproteins.
Physicochemical Properties
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M.Wt
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411.43
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Formula
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C22H22FN3O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(2R,3S,4S)-4-hydroxy-2-(4-(oxazol-5-yl)benzyl)pyrrolidin-3-yl (3-fluorobenzyl)carbamate
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References
1. Diamond PD, et al. Nat Commun. 2026 Feb 24;17:1963.
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