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Chemical Structure : IDX-375
Catalog No.: PC-62828Not For Human Use, Lab Use Only.
IDX-375 is a novel potent, non-nucleoside, allosteric HCV NS5B RdRp inhibitor with IC50 of 15 nM and 5 nM for 1a-H77 HCV NS5B polymerase and 1b-J4 HCV NS5B polymerase, respectively.
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IDX-375 is a novel potent, non-nucleoside, allosteric HCV NS5B RdRp inhibitor with IC50 of 15 nM and 5 nM for 1a-H77 HCV NS5B polymerase and 1b-J4 HCV NS5B polymerase, respectively; has no activity against human cellular polymerases (>75 uM); has an EC50 of 3 nM in HCV replicon luciferase assay; displays excellent antiviral activity on the genotypes 1a and 1b, and a good PK profile in multiple animal models.
HCV Infection
Phase 2 Discontinued
| M.Wt | 643.78 | |
| Formula | C29H50N5O7PS | |
| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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