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Chemical Structure : IGF2BP3 inhibitor AE-848
Catalog No.: PC-21363Not For Human Use, Lab Use Only.
IGF2BP3 inhibitor AE-848 is a small molecule inhibitor of RNA m6A reader insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), inhibits the growth and progression of OC cells by disrupting the stability of the targeted mRNAs of IGF2BP3.
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IGF2BP3 inhibitor AE-848 is a small molecule inhibitor of RNA m6A reader insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), inhibits the growth and progression of OC cells by disrupting the stability of the targeted mRNAs of IGF2BP3.
AE-848 significantly inhibited tumor growth by reducing the expression of tumor-associated antigen (c-MYC/VEGF/Ki67/CDK2) and improving the anti-tumor effect of macrophages.
AE-848 not only could duplicate the above results of knockdown assay but also reduces the expression of c-MYC in M2 macrophages and tumor-associated macrophages and promotes the cytokine IFN-γ and TNF-α secretion.
| M.Wt | 738.95 | |
| Formula | C40H50N8O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chang Shu, et al. Am J Cancer Res. 2023 Oct 15;13(10):4888-4902.
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