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Chemical Structure : IGGi-11me
Catalog No.: PC-20014Not For Human Use, Lab Use Only.
IGGi-11me is a specific, cell-active small molecule inhibitor of GIV-dependent G-protein cell signaling, binds to G-protein α-subunits, specifically disrupts their engagement with GIV/Girdin.
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IGGi-11me is a specific, cell-active small molecule inhibitor of GIV-dependent G-protein cell signaling, binds to G-protein α-subunits, specifically disrupts their engagement with GIV/Girdin.
IGGi-11me was converted to IGGi-11 (Cat# PC-20013) by esterases present in the cytosol of MDA-MB-231 cells.
IGGi-11me specifically inhibits GIV-dependent cancer cell signaling reduced the phosphorylation of Akt at S473 (pAkt) upon EGF stimulation in MDA-MB-231 (IC50=16 uM) and HeLa cells, but not in GIV-depleted cells.
IGGi-11me does not affect GIV-independent G-protein cell signaling.
IGGi-11me specifically inhibits GIV-dependent tumor cell migration, IGGi-11me was approximately four times more potent inhibiting the migration of MDA-MB-231 cells (GIVHigh) than of MCF-7 cells (GIVLow).
IGGi-11me inhibits growth of MDA-MB-231 breast cancer invasive cells, but not of non-transformed MCF-10A cells.
IGGi-11me inhibits MDA-MB-231 cell tumor growth and metastatic invasion in NCr nu/nu athymic nude mice.
| M.Wt | 552.66 | |
| Formula | C25H32N2O8S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jingyi Zhao, et al. Small-molecule targeting of GPCR-independent non-canonical G protein signaling inhibits cancer progression. bioRxiv. 2023 Feb 19;2023.02.18.529092.
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