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Chemical Structure : IGS-1.76
Catalog No.: PC-35410Not For Human Use, Lab Use Only.
IGS-1.76 is a small molecule inhibitor of human NCS-1/Ric8a interaction with affinity of 1.25 uM (hNCS-1).
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IGS-1.76 is a small molecule inhibitor of human NCS-1/Ric8a interaction with affinity of 1.25 uM (hNCS-1); demonstrates improved binding potency over the phenothiazine FD44, decreasing the abnormally high synapse number and enhancing associative learning in a FXS animal model.
| M.Wt | 358.459 | |
| Formula | C22H18N2OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Roca C, et al. J Med Chem. 2018 Jul 17. doi: 10.1021/acs.jmedchem.8b00088.
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