IHCH-2330 | 5-HT2A agonist | Probechem Biochemicals

Chemical Structure : IHCH-2330

IHCH-2330 (IHCH2330)

Catalog No.: PC-28264Not For Human Use, Lab Use Only.

IHCH-2330 is a potent, selective 5-HT2AR agonist with Ki of 7.24 nM and 45.71 nM for 5-HT2AR and 5-HT2BR respectively, simultaneously antagonizing 5-HT2BR.

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Biological Activity

IHCH-2330 is a potent, selective 5-HT2AR agonist with Ki of 7.24 nM and 45.71 nM for 5-HT2AR and 5-HT2BR respectively, simultaneously antagonizing 5-HT2BR.
IHCH-2330 displays 9-, 19-, 24-, 40- and 62-fold selectivity over 5-HT1DR, 5-HT1BR, 5-HT6R, β2-AR and 5-HT1FR, respectively. IHCH-2330 also exhibits negligible agonist activity at the remaining 5-HT receptors, only weak antagonist activity at α1A-AR, α1B-AR, α2C-AR, and M1R.
IHCH-2330 exhibits potent 5-HT2AR agonism in both Gαq and β-arrestin signals with EC50 of 7.08 nM and 44.61 nM respectively.

Physicochemical Properties

M.Wt	449.47
Formula	C23H26F3N3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(2-((2,5-dimethoxy-4-(trifluoromethyl)phenethyl)(methyl)amino)ethyl)-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

References

1. Tang L, et al. Nat Commun. 2026 Sep 17;17(1):9873.

IHCH-2330 (IHCH2330)

Biological Activity

Physicochemical Properties

References

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