IHCH-6122 | 5-HT2A agonist | Probechem Biochemicals

Chemical Structure : IHCH-6122

IHCH-6122 (IHCH6122)

Catalog No.: PC-28311Not For Human Use, Lab Use Only.

IHCH-6122 is a potent agonist of serotonin 2A receptor (5-HT2AR) with Gq EC50 of 97.7 nM (Emax = 109%) and β-arrestin2 recruitment EC50 of 186 nM (Emax =73%), shows antagonist activity at 5-HT2BR, shows antidepressant effects.

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Biological Activity

IHCH-6122 is a potent, selective agonist of serotonin 2A receptor (5-HT2AR) with Gq EC50 of 97.7 nM (Emax = 109%) and β-arrestin2 recruitment EC50 of 186 nM (Emax =73%), shows antagonist activity at 5-HT2BR, shows antidepressant effects.

Physicochemical Properties

M.Wt	217.32
Formula	C13H19N3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(piperazin-1-yl)-5,6,7,8-tetrahydroisoquinoline

References

1. Tang L, et al. Nat Commun. 2026 Sep 17;17(1):9873.

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IHCH-6122 (IHCH6122)

Biological Activity

Physicochemical Properties

References

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