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IHCH-7113

Chemical Structure : IHCH-7113

CAS No.: 313368-85-3

IHCH-7113 (IHCH7113)

Catalog No.: PC-28307Not For Human Use, Lab Use Only.

IHCH-7113 is a selective agonist of serotonin 2A receptor (5-HT2AR) with EC50 of 58.9 nM in Gq BRET assay and 44.7 nM in β-arrestin 2 BRET assays, activates both Gαq-mediated signaling pathways and β-arrestin 2 recruitment pathways and shows antidepressant activity.

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Biological Activity

IHCH-7113 is a selective agonist of serotonin 2A receptor (5-HT2AR) with EC50 of 58.9 nM in Gq BRET assay and 44.7 nM in β-arrestin 2 BRET assays, activates both Gαq-mediated signaling pathways and β-arrestin 2 recruitment pathways and shows antidepressant activity.

Physicochemical Properties

M.Wt 229.33
Formula C14H19N3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(6bR,10aS)-3-Methyl-2,3,6b,7,8,9,10,10a-octahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline

References

1. Dongmei Cao, et al. Science. 2022 Jan 28;375(6579):403-411.

2. Duan W, et al. Chemical reviews. 2024 Jan 10;124(1):124-163.

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