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IHCH-8110

Chemical Structure : IHCH-8110

CAS No.: 3078735-55-1

IHCH-8110 (IHCH8110)

Catalog No.: PC-27530Not For Human Use, Lab Use Only.

IHCH-8110 is a potent, selective non-brain-penetrant, peripheral-restricted serotonin 2A receptor (5-HT2AR) agonist, inhibits CRC progression by activating 5-HT2AR on enteric glial cells, thereby inducing CXCL10 and IL-18 expression to promote CD8+ T cell recruitment and effector polarization within the tumor microenvironment.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    IHCH-8110 is a potent, selective non-brain-penetrant, peripheral-restricted serotonin 2A receptor (5-HT2AR) agonist, inhibits CRC progression by activating 5-HT2AR on enteric glial cells, thereby inducing CXCL10 and IL-18 expression to promote CD8+ T cell recruitment and effector polarization within the tumor microenvironment.

    Physicochemical Properties

    M.Wt 361.53
    Formula C21H35N3O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    Urea, N-(trans-4-aminocyclohexyl)-N′-[[4-(hexyloxy)phenyl]methyl]-N-methyl-

    References

    1. Wen Y, et al. Targeting peripheral 5-HT2AR enhances antitumor immunity in colorectal cancer. Cell. 2026 Aug 4:S0092-8674(26)00826-3.

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