Chemical Structure : IHCH-8110
Catalog No.: PC-27530Not For Human Use, Lab Use Only.
IHCH-8110 is a potent, selective non-brain-penetrant, peripheral-restricted serotonin 2A receptor (5-HT2AR) agonist, inhibits CRC progression by activating 5-HT2AR on enteric glial cells, thereby inducing CXCL10 and IL-18 expression to promote CD8+ T cell recruitment and effector polarization within the tumor microenvironment.
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IHCH-8110 is a potent, selective non-brain-penetrant, peripheral-restricted serotonin 2A receptor (5-HT2AR) agonist, inhibits CRC progression by activating 5-HT2AR on enteric glial cells, thereby inducing CXCL10 and IL-18 expression to promote CD8+ T cell recruitment and effector polarization within the tumor microenvironment.
| M.Wt | 361.53 | |
| Formula | C21H35N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wen Y, et al. Targeting peripheral 5-HT2AR enhances antitumor immunity in colorectal cancer. Cell. 2026 Aug 4:S0092-8674(26)00826-3.

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