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Chemical Structure : IHR-1
Catalog No.: PC-60380Not For Human Use, Lab Use Only.
A novel cell membrane impermeable smoothened antagonist with IC50 of 7.6 nM in Hh-dependent Gli transcriptional activity assay.
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A novel cell membrane impermeable smoothened antagonist with IC50 of 7.6 nM in Hh-dependent Gli transcriptional activity assay; blocks Smo accumulation in the primary cilium without inhibiting SAG-induced pathway response.
| M.Wt | 454.13 | |
| Formula | C20H12Cl4N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Fan CW, et al. Chem Biol. 2014 Dec 18;21(12):1680-9.
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