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Chemical Structure : IIIM-290
Catalog No.: PC-62534Not For Human Use, Lab Use Only.
IIIM-290 (IIIM290) is a potent, orally active cyclin-dependent kinase (CDK) inhiitor with IC50 of 1.9 and 16 nM for Cdk-9/T1 and Cdk-2/A, respectively.
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IIIM-290 (IIIM290) is a potent, orally active cyclin-dependent kinase (CDK) inhiitor with IC50 of 1.9 and 16 nM for Cdk-9/T1 and Cdk-2/A, respectively.
IIIM-290 selectively inhibits Molt-4/MIAPaCa-2 cell growth with GI50 of <1 uM.
IIIM-290 inhibits the cell growth of MIAPaCa-2 cells via caspase-dependent apoptosis, demonstrates in vivo efficacy in pancreatic, colon, and leukemia xenografts at 50 mg/kg, po., without CYP/efflux-pump liability, and mutagenic/genotoxic or cardiotoxic effects.
| M.Wt | 462.323 | |
| Formula | C23H21Cl2NO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bharate SB, et al. J Med Chem. 2018 Feb 22;61(4):1664-1687.
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