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Chemical Structure : IKK16
CAS No.: 1186195-62-9
Catalog No.: PC-63330Not For Human Use, Lab Use Only.
IKK16 is a potent, selective inhibitor of IκB kinase (IKK) with IC50 of 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $138 | In stock | |
| 25 mg | $228 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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IKK16 is a potent, selective inhibitor of IκB kinase (IKK) with IC50 of 40, 70 and 200 nM for IKKβ, IKK complex and IKKα respectively.
IKK16 inhibits TNF-α-stimulated IκB degradation and expression of adhesion molecules E-selectin, ICAM and VCAM with IC50 of 1.0, 0.5, 0.3 and 0.3 uM respectively.
IKK16 inhibits LPS-induced TNF-α release in vivo and neutrophil extravasion in thioglycollate-induced peritonitis models.
| M.Wt | 535.107 | |
| Formula | C28H31ClN6OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(4-Pyrrolidin-1-yl-piperidin-1-yl)-[4-(4-benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)phenyl]carboxamide hydrochloride |
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1. Waelchli R, et al. Bioorg Med Chem Lett. 2006 Jan 1;16(1):108-12.
2. Thein S, et al. Biochem Biophys Res Commun. 2014 Jul 18;450(1):550-4.
3. Sordi R, et al. Mol Med. 2015 Jun 18;21:563-75.
4. Liu JC, et al. Cell Rep. 2018 Apr 3;23(1):112-126.
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