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IKK2-IN-8

Chemical Structure IKK2-IN-8

CAS No.: 1266240-87-2

IKK2-IN-8

Catalog No.: PC-63117Not For Human Use, Lab Use Only.

IKK2-IN-8 is a potent, selective IKK2 inhibitor with IC50 of 6 nM, displays >40-fold selectivity over IKK1 (IC50=230 nM).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

IKK2-IN-8 is a potent, selective IKK2 inhibitor with IC50 of 6 nM, displays >40-fold selectivity over IKK1 (IC50=230 nM); inhibits lipopolysaccharide (LPS) induced TNFα production in human PBMCs with IC50 of 80 nM.

Physicochemical Properties

M.Wt 380.47
Formula C19H20N6OS
CAS No. 1266240-87-2
Storage
Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 3 Month
Shipping
Solubility

Chemical Name

(S)-N-(1-(3-(8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl)phenyl)ethyl)acetamide

Clinical Information

References

1. Dyckman AJ, et al. Bioorg Med Chem Lett. 2011 Jan 1;21(1):383-6.

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