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IMA-1

Chemical Structure : IMA-1

CAS No.: 2315406-63-2

IMA-1 (ALOX12-ACC1 inhibitor IMA-1)

Catalog No.: PC-72818Not For Human Use, Lab Use Only.

IMA-1 (ALOX12-ACC1 inhibitor IMA-1) is a small molecule that interrupt the arachidonate 12-lipoxygenase (ALOX12)-acetyl-CoA carboxylase 1 (ACC1) interaction.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

IMA-1 is a small molecule that interrupt the arachidonate 12-lipoxygenase (ALOX12)-acetyl-CoA carboxylase 1 (ACC1) interaction.
IMA-1 markedly blocked diet-induced NASH progression in both male mice and Cynomolgus macaque therapeutic models.
The anti-NASH efficacy of IMA-1 was comparable to ACC inhibitor in both species.
IMA-1 directly binds to a pocket in ALOX12 proximal to its ACC1-interacting surface instead of inhibiting ALOX12 lipoxygenase activity.
IMA-1 treatment did not elicit hyperlipidemia, a known side effect of direct inhibition of ACC enzymatic activity, in both mice and macaques.

Physicochemical Properties

M.Wt 617.644
Formula C27H27N3O10S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2S,3S,4S,5R,6S)-6-(2-(((4-(N-(benzo[d]thiazol-2-yl)sulfamoyl)phenyl)amino)methyl)-6-methoxyphenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid

References

1. Xiao-Jing Zhang, et al. Sci Transl Med. 2021 Dec 15;13(624):eabg8116.

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