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Chemical Structure : IMB0901
Catalog No.: PC-21391Not For Human Use, Lab Use Only.
IMB0901 is a small molecule myostatin (MSTN) inhibitor that inhibits the MSTN promoter activity, the MSTN signaling pathway, and the MSTN positive feedback regulation.
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IMB0901 is a small molecule myostatin (MSTN) inhibitor that inhibits the MSTN promoter activity, the MSTN signaling pathway, and the MSTN positive feedback regulation.
IMB0901 at a concentration of 2.5 or 5 μM significantly neutralized the MSTN signaling pathway triggered by 10 ng/ml MSTN.
IMB0901 at a dose of 5 μM significantly inhibited the P-SMAD and increased the P-FOXO3a in atrophied C2C12 myotubes.
IMB0901 upregulated the expressions of myotube markers and protected the myotube morphology.
IMB0901 lowered the expressions of Atrogin-1, MuRF-1, and ubiquitin and promoted phosphorylation of AKT, mTOR, and P70S6K in atrophied C2C12 myotubes.
IMB0901 (30 mg/kg) inhibited the weight loss of body, quadriceps, and gastrocnemius induced by C26 tumor model, decreased the expression of two E3 ligases Atrogin-1 and MuRF-1 in the quadriceps in vivo.
IMB0901 is a promising leading compound for the management of muscle atrophy induced by cancer cachexia.
| M.Wt | 352.22 | |
| Formula | C15H15Cl2N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Dong Liu, et al. Skelet Muscle. 2019 Mar 28;9(1):8.
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